Perhaps fearing trade to a different authoritarian government (aren't they all?) all 50 states have started petitions to secede from the union. Perhaps that is Puerto Rico's goal, gain statehood and then use the constitutional right of secession to escape the clutches of the leviathan. At the time this is being written the lone star state is the only state to gain any real traction holding over 100,000 signatures on its online petition. Keep in mind that is less than 0.4% of the Texan population.
After that is sovereignty, certainly many federal laws hinder economic growth for many states, but with the size of the us military and what happened 150 years ago it is unlikely to assume that the sovereignty would be respected.
So will any states secede? Likely no. But it wouldn't hurt to start looking at new flag designs, it really is hard to say what will result from the recent referendum.
I like this one.